APPENDIX D: RESEARCH GRANTS AWARDED DURING 2006-7
FULL GRANTS FUNDED BY BIOMEDICAL AND THERAPEUTIC RESEARCH COMMITTEE
Professor W MacNee, Professor D Newby, Professor K Donaldson, Dr N Mills ( CZB/4/424)
Novel determinants of cardiovascular risk in patients with chronic obstructive pulmonary disease: potential mechanisms and therapeutic targets
£192,437 over 2 years
Dr S Farrington, Dr A Tenesa, Professor H Campbell, Professor M Dunlop ( CZB/4/449)
The role of base excision repair defects in predisposition to colorectal cancer
£221,339 over 3 years
Dr Q Zhao, Professor E Abel ( CZB/4/441)
Development and evaluation of a novel anti-bacterial nanocomposite coating for medical devices and implants
£93,087 over 2 years
Dr B Fleck, Professor A Wright, Professor H Campbell, Dr J Wilson, Dr V Karunaratne ( CZB/4/438)
The genetic analysis of ocular morphometric traits related to primary open angle glaucoma susceptibility in the population isolate of Orkney (the glaucoma inheritance study of Orkney, GISO)
£223,739 over 3 years
Professor J Norman, Professor W Martin,
Nr J Norrie, Dr S Nelson,
Dr F MacKenzie, Dr P Owen, Dr K Hanretty,
Dr S Cooper, Professor A Calder
( CZB/4/408)
The myometrial effects of prolonged in vivo treatment with progesterone in pregnancy
£216,554 over 27 months
Dr D Connelly, Dr M MacDonald, Dr M Petrie, Professor S Cobbe, Professor J McMurray, Professor H Dargie ( CZB/4/475)
Radiofrequency ablation for atrial fibrillation in advanced chronic heart failure: a pilot study
£150,654 over 18 months
Dr J Gardner-Medwin, Professor N Sattar, Professor R Sturrock,
Professor I McInnes, Mr J McColl ( CZB/4/470)
Evidence of risk for the development of premature cardiovascular disease in juvenile idiopathic arthritis?
£223,470 over 3 years
Dr A Flapan, Dr S Wild, Mr S McLean, Mr P Connor ( CZB/4/413)
Strategies for optimal reperfusion in ST segment evaluation myocardial infarction. A feasibility study for provision of primary percutaneous coronary intervention and pre-hospital thrombolytic therapy in Scotland
£275,659 over 28 months
Dr E Pearson, Professor A Hattersley, Dr A Doney, Dr CNA Palmer, Professor CR Wolf, Professor A Morris, Professor P Donnan ( CZB/4/463)
Development and validation of a therapeutic response model to investigate the aetiology of type 2 diabetes
£79,960 over 3 years
Professor IJ Deary, Mr A Gow, Dr J Starr, Dr T Bates ( CZB/4/505)
Testing the common cause hypothesis of cognitive ageing in the Lothian Birth Cohort 1921
£175,326 over 18 months
Mr S McNally, Dr JA Ross, Dr D Kluth ( CZB/4/442)
Induction of hemoxygenase-1: A therapeutic approach to reduce hepatic ischaemia-reperfusion injury in liver surgery
£223,157 over 3 years
Dr A Hill, Dr M Murray, Professor A Greening, Professor C Haslett, Dr J Simpson, Dr JRW Govan ( CZB/4/451)
Can long term nebulised gentamicin reduce the bacterial burden, break the vicious cycle of inflammation and improve quality of life in patients with bronchiectasis?
£224,926 over 2 years
Dr M Helfrich, Dr F Coxon ( CZB/4/495)
Functional and ultrastructural studies in osteopetrosis
£201,777 over 2 years
Dr BS Pickard, Professor D Blackwood, Professor DJ Porteous, Dr WJ Muir ( CZB/4/498)
Identifying functional mutations in the ABCA13 gene contributing to increased risk of schizophrenia
£136,613 over 1 year
Dr D Newby, Dr NN Lang ( CZB/4/520)
Gap junctions and endothelium-derived hyperpolarising factor responses- new targets for the augmentation of endothelial function?
£53,176 over 18 months
Professor KEL McColl, Dr J Manning ( CZB/4/485)
Investigation of effect of nitrate in saliva on gastro-oesophageal reflux
£204,874 over 3 years
Dr JG Moss, Dr O Wu, Dr KG Cooper,
Dr RD Edwards, Professor G Murray, Professor MA Lumsden ( CZB/4/484)
Long term (3-5 years) follow up and MRI imaging of the REST trial cohort
£125,911 over 33 months
Ms KL Evans, Dr WJ Muir, Professor D Blackwood, Professor DJ Porteous ( CZB/4/499)
Refinement of a genetic locus for bipolar disorder on human chromosome 4p
£137,578 over 1 year
Dr M Eddleston, Professor D Bateman,
Dr J Goddard, Professor D Webb, Dr N Uren ( CZB/4/459)
Mechanisms for an effect of N-acetylcysteine on renal function after exposure to radio-graphic contrast material
£222,060 over 18 months
Dr Z Miedzybrodzka, Professor D St Clair,
Dr B Mueller, Dr M Neves-Pereira ( CZB/4/556)
The role of regulation of a translocation associated gene in familial and sporadic autism
£197,185 over 2 years
BIOMEDICAL AND THERAPEUTIC RESEARCH TRANSLATIONAL GRANTS
Dr G Rena ( CZB/4/512)
Comparison of the effects of insulin and EGCG action on human skeletal muscle and expression of insulin-regulated genes
£40,822
Professor J Wardlaw, Dr C Sudlow, Professor J McCulloch ( CZB/4/517)
A systematic review of experimental models of lacunar stroke: linking models to the human disease
£52,570
Professor J Timmons ( CZB/4/514)
Characterising mi RNA expression in male and female muscle and adipose tissue samples: identification of novel obesity and diabetes biomarkers
£55,512
Professor A Baker, Dr C Delles, Professor A Dominiczak ( CZB/4/506)
Optimisation of gene delivery to human saphenous vein for application to clinical trials
£74,784
Professor J Satsangi, Dr G Ho, Professor D Porteous, Dr E Nimmo, Professor M Dunlop,
Dr A Tenesa ( CZB/4/540)
Investigation into the genetic determinants of corticosteroid resistance: Development and application of a pharmacogenetic model in inflammatory bowel disease
£61,661
Dr A Horne, Professor H Critchley, Dr A King,
Dr S Cameron ( CZB/4/513)
Effects of Chlamydial infection on natural anti-microbial expression in the female reproductive tract - could altered anti-microbial expression be exploited as a marker for ectopic pregnancy?
£48,418
Mr P Bryant, Dr D Adamson, Professor A Riches ( CZB/4/510)
Topoisomerase IIx expression level as a determinant of chromosomal radiosensitivity of T-lymphocytes from sporadic breast cancer cases
£47,831
Professor R Anderson, Dr P de Sousa,
Dr S Pickering, Dr K Thong ( CZB/4/537)
Cumulus cell biomarkers reflect oocyte and embryo developmental competence and pregnancy potential
£57,727
Professor D Stott, Professor G Lowe, Professor N Sattar, Professor I Ford ( CZB/4/530)
Proinflammatory cytokines as biomarkers for risk of stroke
£25,518
Professor I Whittle, Professor J McCulloch,
Dr C Smith ( CZB/4/486)
Differential proteomics of normal brain and gliomas: clinical and mechanistic analysis
£64,767 over 9 months
Dr H Cubie, Dr K Cushieri, Dr D Brewster,
Dr A Williams, Ms C Graham ( CZB/4/538)
Distribution of HPV types associated with anogenital cancers in Scotland and implications for the potential impact of new HPV vaccines
£50,149
Dr M Macleod, Professor P Sandercock,
Dr P Kelly ( CZB/4/531)
Improving the design, conduct and reporting of animal studies in experimental stroke
£46,069
Dr H Jorgensen, Dr J Mountford ( CZB/4/524)
Measurement and modulation of tyrosine kinase inhibitor drug levels in chronic myeloid leukaemia
£40,510
Dr T Bates ( CZB/4/536)
Risk genes for Dyslexia: Translating familial risk research into specific risk genes
£46,491
FULL GRANTS FUNDED BY HEALTH SERVICES RESEARCH COMMITTEE
Professor R O'Carroll, Professor P Hayes,
Mr J Forsythe, Dr G Masterton, Dr S Potts ( CZH/4/348)
Functional and psychosocial outcome in living liver donors and recipients in Scotland
£214,595 over 3 years
Professor F Fowkes, Dr A Lee, Dr P Allan,
Dr C Evans, Professor C Ruckley ( CZH/4/397)
Lifestyle and clinical factors determining progression of venous disease in the legs: Edinburgh Vein Study
£205,980 over 30 months
Dr H Pinnock, Dr S Murray, Dr A Worth, Professor A Sheikh, Mr M Porter, Professor W MacNee, Dr M Kendall, Ms D Wilkinson, Dr P Levack ( CZH/4/301)
A breath of fresh air: improving care and services for patients living and dying with chronic obstructive pulmonary disease, and their carers
£205,485 over 3 years
Dr M Watson, Professor M Johnston, Professor C Bond, Dr V Entwistle, Dr A Lee ( CZH/4/376)
Improving consumer communication during consultations for non-prescription medicines in community pharmacies
£174,606 over 3 years
Ms S Hagen, Mrs D Stark, Dr C Glazener, Ms L Sinclair, Mr J Norrie, Professor D Wilson ( CZH/4/377)
A multi-centre randomised controlled trial of a pelvic floor muscle training intervention for women with pelvic organ prolapse
£289,681 over 3 years
Professor S Battacharya, Dr Mark Hamilton, Miss AJ Lee, Professor A Templeton, Dr J Kurinczuk,
Dr M Porter ( CZH/4/391)
A study of the epidemiology of infertility in the North East of Scotland
£69,461 over 1 year
Professor DW Johnston, Mrs B Farquharson,
Dr MC Jones, Professor M Johnston, Dr J Hay ( CZH/4/394)
Stress in NHS-24 nurses: level, determinants and consequences assessed using psychological, physiological and behavioural measures
£219,470 over 2 years
Dr K MacIntyre, Dr J Chalmers, Mr A Redpath,
Dr S Capewell, Professor JVV McMurray, Dr M Walters, Dr P Jhund ( CZH/4/389)
Stroke in Scotland 1986 - 2004: Epidemiology and impact on population and health care
£194,453 over 2 years
Professor K Millar, Professor RR Welbury, Dr NS Morton, Dr MT Hosey, Professor A Bowman, Dr JA Asbury ( CZH/4/382)
Randomised clinical trial of the effects of total intravenous anaesthesia ( TIVA: propofol) versus volatile anaesthesia (sevoflurance/N20) on children's post-operative cognition, behaviour and physical morbidity
£225,000 over 3 years
Dr CM Wright, Dr D Young, Dr H Minnis, Professor A Le Couteur, Dr A Sherriff ( CZH/4/411)
Developing an infancy feeding and eating scale
£109,945 over 18 months
Professor J Reilly, Dr M Fewtrell, Dr J Wells ( CZH/4/413)
Is exclusive breast-feeding adequate to meet infant energy needs at 6 months?: Longitudinal studies of infant energy balance
£27,186 over 2 years
Dr CE Bucknall, Dr P Cotton, Dr JGF Cleland,
Dr R Stevenson, Dr M Cotton, Dr A McConnachie, Dr C Morrison ( CZH/4/246)
Glasgow Supported Self-management randomised controlled Trial for patients with moderate to severe COPD - GsuST
£173,285 over 3 years
Dr J Morrison, Dr P Wilson, Professor M Sutton,
Dr M Smith, Dr A Power, Ms R Munoz-Arroyo, Mrs M Maxwell, Ms S MacDonald, Mr D Bailey, Ms M-J Anderson ( CZH/4/400)
Depression and long term work incapacity in Scotland: the role of the GP
£215,979 over 2 years
Dr B Cuthbertson, Professor A Grant, Mr J Norrie, Dr J Kinsella, Miss J Brittenden, Professor M Campbell, Mr L Vale, Dr S Stott ( CZH/4/392)
Pragmatic multi-centre randomised trial of (1) routine postoperative ICU care and (2) pre-operative fluid loading in high-risk surgical patients undergoing major elective and urgent surgery
£225,817 over 2 years
Professor K Davidson, Mr S Palmer, Mr J Norrie,
Dr H Seivewright, Dr A Gumley, Professor P Tyrer ( CZH/4/435)
Prospective 5 years follow-up of UK patients with borderline personality disorder
£225,000 over 18 months
Professor R Bhopal, Ms H Brown, Mr C Povey,
Dr J Chalmers, Mr D Brewster, Ms J Jamieson,
Dr C Fishbacher ( CZH/4/432)
Ethnicity and health in Scotland: Making the information desert bloom a retrospective cohort study linking health and census databases
£224,975 over 30 months
Dr G Leese, Mr W Morrison, Dr M Murphy, Professor A Morris ( CZH/4/395)
Long-term morbidity in patients with primary hyperparathyroidism - a population based study
£137,752 over 22 months
PROGRAMME GRANTS
Dr I McEwan, Dr A MacKenzie ( CZB/4/477)
Deregulation of androgen receptor signalling in prostate cancer
£455,277 over 3 years
Professor R Steele, Professor D Weller,
Dr A Walker, Dr D Brewster, Mr R Black, Ms C Morton,m Professor F Carey, Dr M Kenicer,
Dr C Fraser, ( CZH/6/4)
Establishing a Bowel Screening Research Unit
£436,981 over 5 years
SMALL GRANTS IN HEALTH SERVICES RESEARCH
Dr A Talbot, Dr H Frenkel, Professor R Barbour,
Dr M Brady, Professor DJ Stott ( CZG/2/246)
Staff attitudes, behaviours and perceived barriers towards oral health care provision in stroke units.
£20,694 over 1 year
Professor G Raab, Dr JM Davis, Dr L Elliot,
Ms H Storkey, Ms M Henderson ( CZG/2/264)
Development of instruments and procedures for a randomised controlled trial to evaluate the Zero Tolerance Respect package in Midlothian Primary Schools
£22,415 over 11 months
Dr B Cuthbertson, Dr S Close, Dr G Christie,
Mr G Prescott ( CZG/2/202)
A scoring system to allow early recognition and intervention of critical illness in acute medical admissions in a medical admissions and respiratory unit environment
£22,500 over 7 months
Professor MEJ Lean, Dr D Grieve, Dr M Cotton,
Dr A Mullen ( CZG/2/261)
Does oral creatine supplementation enhance recovery from COPD exacerbation?
£20,940 over 6 months
Dr L Paul, Mr A McFadyen, Dr G Leese, Dr B Ellis ( CZG/2/250)
The effect of a secondary task on the gait parameters of diabetic elderly people with and without peripheral neuropathy and it's association with falls - A pilot study
£22,451 over 8 months
Professor IA Greer, Dr C Calderwood ( CZG/2/254)
Epidemiology of venous thromboembolism in the Scottish population
£8,736 over 9 months
Dr F Dunn, Dr J Shand, Dr N Goodfield,
Dr I MacLeod, Mr N Hawkins, Dr S Jenkins ( CZG/2/266)
Evaluation of the potential impact of Multi-Slice CT Scanning on waiting lists for invasive coronary angiography in the West of Scotland
£109,692 over 2 years (co-funded by Healthcare Planning Division)
Dr R Al-Shahi ( CZG/2/265)
A digital archive and web-based reviewing system for the imaging in intracranial vascular malformations: a tool to measure observer variation and facilitate
e-learning
£33,170 over 1 year
Dr J McLay, Dr A Lee, Dr DN Bateman,
Dr D McCaig, Professor CM Bond, Professor PJ Helms, Dr D Stewart ( CZG/2/267)
A pilot study to evaluate a community pharmacy based monitoring system to identify adverse drug reaction associated with paediatric medicines use
£22,501 over 6 months
Dr B Duncan, Ms J McIntosh, Dr C Johnman,
Dr J Galloway ( CZG/2/278)
Exploring understandings of sexual risk and sexual health among heterosexual young people with antisocial behaviour problems
£49,927 over 6 months
Dr L Graham, Dr A Fraser ( CZG/2/282)
Estimating mortality of people who have been in prison in Scotland
£8,000 over up to 24 months (includes contribution from ISD)
Ms I Schofield, Professor D Tolson, Professor D Stott ( CZG/2/248)
Validity of the 4 item Abbreviated Mental Test for older people in an Accident and Emergency Department
£50,000 over 1 year
Dr A Elliot, Professor B Smith, Professor A Lee,
Dr N Torrance ( CZG/2/287)
Health impact of chronic pain: A cohort record linkage study
£39,796 over 1 year